General Information

  • ID:  hor001611
  • Uniprot ID:  P42562
  • Protein name:  FMRFamide-like neuropeptide YLRF-amide
  • Gene name:  NA
  • Organism:  Hirudo medicinalis (Medicinal leech)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Hirudo (genus), Hirudinidae (family), Hirudiniformes (suborder), Hirudinida (order), Hirudinea (subclass), Clitellata (class), Annelida (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YLRF
  • Length:  4(1-4)
  • Propeptide:  YLRF
  • Signal peptide:  NA
  • Modification:  T4 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001611_AF2.pdbhor001611_ESM.pdb

Physical Information

Mass: 65140 Formula: C30H43N7O6
Absent amino acids: ACDEGHIKMNPQSTVW Common amino acids: FLRY
pI: 9.35 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 2
Hydrophobicity: 20 Boman Index: -716
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 97.5
Instability Index: 5565 Extinction Coefficient cystines: 1490
Absorbance 280nm: 496.67

Literature

  • PubMed ID:  1686933
  • Title:  Identification of RFamide neuropeptides in the medicinal leech.